Heart rate variability as a predictor of intraoperative autonomic nervous system homeostasis
Authors' conclusion
HRV mirrors the trend of the Narcotrend Index used to monitor depth of hypnosis and the inhibitory influence of the anesthetic sevoflurane on the autonomic nervous system.
Study context
- Population
- Male patients undergoing Da-Vinci robotic-assisted radical prostatectomy under sevoflurane anesthesia, Mannheim University Medical Center
- Participants
- 31 patients
- Outcome
- Concordance (repeated measures correlation, rrm) between heart rate variability (HRV), Narcotrend Index (depth of hypnosis) and sevoflurane MAC across the surgical procedure
Methodological detailsnon-blinded, proof-of-concept
- Non-blinded
- Proof-of-concept
Main finding
As reported in the abstract
Repeated measures correlation (rrm) across all measures
- Narcotrend Index vs SDNN, rrm (p < 0.001)
- 0.2
- Narcotrend Index vs low frequency (LF), rrm (p = 0.04)
- 0.09
- Narcotrend Index vs LF/HF ratio, rrm (p = 0.002)
- 0.11
- Minimal alveolar concentration (MAC) vs SDNN, rrm (p < 0.001)
- −0.28
- MAC vs LF, rrm (p < 0.001)
- −0.06
- MAC vs LF/HF ratio, rrm (p < 0.001)
- −0.18
- MAC vs Narcotrend Index, rrm (p < 0.001)
- −0.49
Observational data: associations, not effects.
Original publication
Heart rate variability as a predictor of intraoperative autonomic nervous system homeostasis. J Clin Monit Comput. Published 13 July 2024. doi:10.
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