Respiratory failure & ventilation
Heliox ventilation in elderly, hypertensive ICU patients improves microcirculation: A randomized controlled study
Authors' conclusion
Heliox ventilation improves blood pressure and microcirculation in elderly hypertensive patients and may resolve the limitations of traditional nitrogen-oxygen ventilation.
Study context
- Population
- Patients over 65 years with essential hypertension undergoing invasive mechanical ventilation in ICU
- Participants
- 38 participants
- Comparison
- Heliox ventilation vs nitrogen-oxygen ventilation
- Helioxn = 19
- Nitrogen-oxygenn = 19reference
- Primary endpoint
- Hemodynamics, especially microcirculation (sublingual microcirculation parameters)
Primary result
As reported in the abstract
Sublingual microcirculation indexes · 3 h
- Sublingual microcirculation indexes improved in Heliox vs Nitrogen-oxygen
- p < 0.05
Further findings
Airway pressure, lactic acid, BP, ScvO2, rSO2
- Heliox vs Nitrogen-oxygen: decreased airway pressure and lactic acid; increased BP, ScvO2 and rSO2
- P < 0.05
SpO2 · 1 h vs 0 h
- SpO2 increased in both groups after 1 h vs 0 h, then remained stable
- P < 0.001
Original publication
Heliox ventilation in elderly, hypertensive ICU patients improves microcirculation: A randomized controlled study. J Crit Care. Published 12 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →