Hemoperfusion during extracorporeal membrane oxygenation: an updated systematic review and meta-analysis of 8,151 patients
Pooled resultResult — go to the resultOdds ratio 0.98 95% CI 0.49–1.94Authors' conclusion
In patients receiving extracorporeal membrane oxygenation, hemoperfusion did not reduce mortality and may be associated with increased mortality in randomized controlled trials.
Study context
- Population
- Adults receiving extracorporeal membrane oxygenation (ECMO)13 studies (3 RCTs, 10 non-RCTs)
- Participants
- 8,151 adults
- Comparison
- ECMO plus hemoperfusion vs ECMO alone
- Outcome
- All-cause mortality
Methodological detailsprespecified subgroup analyses, trial sequential analysis, Trial Sequential Analysis (TSA): evidence insufficient to confirm a mortality benefit, Most studies at moderate to serious risk of bias
- Prespecified subgroup analyses
- Trial sequential analysis
- TSA: evidence insufficient to confirm a mortality benefit
- Most studies at moderate to serious risk of bias
Pooled result
As reported in the abstract
Odds ratio
0.98
95% CI 0.49–1.94
P = 0.95
ECMO + HP vs ECMO alone
OR 0.98 (95% CI 0.49–1.94); P = 0.95
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality, RCTs (subgroup)I2 = 34% | 4.96 (1.67–14.77) | P = 0.004 | |
| All-cause mortality, non-RCTs (subgroup)I2 = 79% | 0.58 (0.25–1.33) | P = 0.20 | |
| All-cause mortality, VA-ECMO (subgroup)I2 = 47% | 0.80 (0.41–1.58) | P = 0.53 | |
| All-cause mortality, VV-ECMO (subgroup)I2 = 77% | 1.23 (0.30–4.99) | P = 0.77 | |
| All-cause mortality, VA-ECMO cardiogenic shock (subgroup)I2 = 22% | 0.58 (0.31–1.09) | P = 0.09 | |
| All-cause mortality, VA-ECMO cardiac arrest (subgroup)I2 = 26% | 2.42 (0.71–8.25) | P = 0.16 | |
| 0.050.21520Odds ratio (log scale) |
Other clinical outcomes
- No significant differences
Safety
Complications
- No significant differences
Original publication
Hemoperfusion during extracorporeal membrane oxygenation: an updated systematic review and meta-analysis of 8,151 patients. Crit Care. Published 19 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →