Hemorrhage and thrombosis in COVID-19-patients supported with extracorporeal membrane oxygenation: an international study based on the COVID-19 critical care consortium
Main finding · ICU mortalityResult — go to the resultAdjusted hazard ratio 1.60 95% CI 1.28–1.99Authors' conclusion
Coagulation disorders are frequent in COVID-19 ARDS patients receiving ECMO. Bleeding events contribute substantially to mortality in this cohort.
Study context
- Population
- Adults with severe COVID-19 requiring extracorporeal membrane oxygenation (ECMO), COVID-19 Critical Care Consortium database, centers globally, 01/2020 to 06/2022
- Participants
- 1,248 adults
- Exposure
- Hemorrhagic vs Neither
- Hemorrhagicn = 252
- Thromboticn = 165
- Bothn = 52
- Outcome
- ICU mortality associated with bleeding and clotting disorders
Methodological detailsinternational multicentre registry
- International multicentre registry
Main finding
ICU mortality
Adjusted hazard ratio
1.60
95% CI 1.28–1.99
P < 0.001
Hemorrhagic vs Neither
aHR 1.60 (95% CI 1.28–1.99); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Coagulation complications (any)
- Coagulation complications reported
- 469 (38%)
- Hemorrhagic complications, among those with complications
- 252 (54%)
- Thrombotic complications, among those with complications
- 165 (35%)
- Both, among those with complications
- 52 (11%)
Death and causes of death
- Death
- 617 of the 1248 (49.4%)
- Multiorgan failure
- 257 of 617 [42%]
- Respiratory failure
- 130 of 617 [21%]
- Septic shock
- 55 of 617 (8.9%)
Original publication
Hemorrhage and thrombosis in COVID-19-patients supported with extracorporeal membrane oxygenation: an international study based on the COVID-19 critical care consortium. J Intensive Care. Published 6 May 2024. doi:10.
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