Respiratory failure & ventilation
High Airway Occlusion Pressure Is Associated with Dyspnea and Increased Mortality in Critically Ill Mechanically Ventilated Patients
Primary result · 90-day mortalityResult — go to the resultHazard ratio 1.19 95% CI 1.04–1.37Authors' conclusion
In patients receiving invasive MV, abnormally high P0.1 values may suggest dyspnea and are associated with higher mortality and prolonged duration of MV.
Study context
- Population
- Communicative patients intubated >24 hours in 10 French ICUs
- Participants
- 260 patients
- Comparison
- P0.1 >3.5 vs 1.5–3.5 vs <1.5 cm H2O
Methodological detailsmulticentre
- Multicentre
Primary result
90-day mortality · 90 days
Hazard ratio
1.19
95% CI 1.04–1.37
P = 0.011
By group
P0.1 (per 1 cm H2O)
HR 1.19 (95% CI 1.04–1.37); P = 0.011
Per 1 cm H2O, as printed
As reported in the abstract
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Duration of MVIndependently associated with longer duration | 1.10 (1.02–1.19) | P = 0.016 | |
| 0.512Hazard ratio (log scale) |
P0.1 at enrollment and distribution
- P0.1 at enrollment, cm H2O
- 1.9 (1-3.5)
- P0.1 >3.5 cm H2O
- 24%
- P0.1 1.5–3.5 cm H2O
- 37%
- P0.1 <1.5 cm H2O
- 39%
- Median time of ventilation 4 days
Independent factors associated with P0.1 (multivariable linear regression)
- Dyspnea
- P = 0.037
- Respiratory rate
- P < 0.001
- PaO2
- P = 0.008
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
High Airway Occlusion Pressure Is Associated with Dyspnea and Increased Mortality in Critically Ill Mechanically Ventilated Patients. Am J Respir Crit Care Med. Published 15 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →