High-dimensional flow cytometry identifies immune signatures associated with septic shock severity in critically ill postoperative patients
Authors' conclusion
Septic shock is associated with a distinct immune signature characterized by reduced dendritic cells and NK-like cells. Integration of immune profiling with routine biomarkers is associated with improved discrimination of disease severity in this setting
Study context
- Population
- Postoperative ICU patients
- Participants
- 219 patients
- Exposure
- Septic shock vs sepsis vs non-septic ICU
- Non-septic ICUn = 77reference
- Sepsisn = 62
- Septic shockn = 80
- Outcome
- Immune cell alterations and association with septic shock
Methodological detailsmulticentre, spectral flow cytometry, external validation by single-cell RNA sequencing
- Multicentre
- Spectral flow cytometry
- External validation by single-cell RNA sequencing
Main finding
As reported in the abstract
Combined model AUC
0.870
Observational data: associations, not effects.
Further findings
External validation (single-cell RNA sequencing)
- Confirmed reduced dendritic and NK-like populations; transcriptional alterations consistent with immune and metabolic dysregulation
Original publication
High-dimensional flow cytometry identifies immune signatures associated with septic shock severity in critically ill postoperative patients. Anaesth Crit Care Pain Med. Published 14 July 2026. doi:10.
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