The CD4/CD8 ratio as an immune phenotype improves risk stratification for sepsis-associated acute kidney injury: A single-center, multi-ICU Chinese cohort study
Authors' conclusion
This study establishes a U-shaped association between the CD4/CD8 ratio and SA-AKI risk, with the nadir of risk at a ratio of 1.5-2.5.
Study context
- Population
- Adult septic ICU patients, China
- Participants
- 349 patients
- Exposure
- Clinical model with vs without the CD4/CD8 ratio for predicting sepsis-associated acute kidney injury (SA-AKI)
- Outcome
- Sepsis-associated AKI (SA-AKI) risk
Methodological detailssingle-center, multi-ICU
- Single-center
- multi-ICU
Main finding
As reported in the abstract
Prediction of SA-AKI
| Group | AUC |
|---|---|
| CD4/CD8-enhanced model | 0.788 |
| Clinical model | 0.738 |
AUC
CD4/CD8-enhanced model0.788
Clinical model0.738
- Improved risk reclassification, net reclassification improvement (NRI)
- 0.57 (95% CI 0.40-0.74)
- Improved risk reclassification, integrated discrimination improvement (IDI)
- 0.06 (95% CI 0.03-0.09)
Observational data: associations, not effects.
Original publication
The CD4/CD8 ratio as an immune phenotype improves risk stratification for sepsis-associated acute kidney injury: A single-center, multi-ICU Chinese cohort study. J Crit Care. Published 14 April 2026. doi:10.
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