High expression of L-GILZ transcript variant 1 (glucocorticoid-induced leucine zipper (GILZ) TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration
Authors' conclusion
High expression of GILZ TV 1 is associated with a higher 30-day sepsis mortality rate.
Study context
- Population
- Sepsis patients meeting Sepsis-3 criteriaplus U937 cell line (n = 3)
- Participants
- 121 patients
- Exposure
- High vs lower GILZ transcript variant 1 expression
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Main finding
As reported in the abstract
30-day mortality by GILZ TV 1 expression
Increased GILZ TV 1 within initial day of sepsis onset: fold rise in mortality
2.2
95% CI 1.2–4.3
Increased GILZ TV 1 by day eight: fold increase in mortality
8.5
95% CI 2.0–36.4
Observational data: associations, not effects.
Further findings
High ratio of GILZ TV 1 to all GILZ TVs in patients receiving hydrocortisone (subgroup)
- Fold higher mortality rate
- 2.3
GILZ TV 1 expression in U937 cells
- Enhanced by glucocorticoids; unaffected by LPS
GILZ TV 1 expression in septic patients
- Increases over course of sepsis and in response to hydrocortisone
Original publication
High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration. Crit Care. Published 12 August 2024. doi:10.
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