Respiratory failure & ventilation
High-flow nasal cannula oxygen versus conventional oxygen therapy for acute respiratory failure due to COVID-19: a systematic review and meta-analysis
Authors' conclusion
In patients with acute respiratory failure due to COVID-19, HFNC reduced the need for intubation and shortened length of stay in hospital without significant decreased risk of mortality.
Study context
- Population
- Adults with acute respiratory failure due to COVID-1920 studies (6 randomized controlled trials (RCTs), 14 observational)
- Participants
- 8,383 adults
- Comparison
- HFNC vs conventional oxygen therapy
- Outcome
- Risk of intubation and mortality across RCTs
Methodological detailsfixed-effects or random-effects meta-analysis, observational studies for sensitivity analyses
- Fixed-effects or random-effects meta-analysis
- Observational studies for sensitivity analyses
Pooled result
As reported in the abstract
Intubation and mortality (6 RCTs, 2509 patients)
HFNC vs COTRelative risk (95% CI)P value
Intubation
0.89(0.80–0.98)
P = 0.02Mortality
0.93(0.77–1.11)
P = 0.40Further pooled results
Hospital LOS
- Reduced with HFNC vs COT
Original publication
High-flow nasal cannula oxygen versus conventional oxygen therapy for acute respiratory failure due to COVID-19: a systematic review and meta-analysis. Ann Intensive Care. Published 23 November 2023. doi:10.
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