High-Flow Nasal Oxygen versus Mechanical Ventilation Through a Laryngeal Mask During General Anesthesia Without Muscle Paralysis: A Randomized Clinical Trial
Primary resultResult — go to the resultAbsolute difference 0 95% CI 3%Authors' conclusion
High-flow nasal oxygen is noninferior to laryngeal mask ventilation for intraoperative respiratory support during 30-minute general anesthesia without muscle paralysis.
Study context
- Population
- ASA I–II patients undergoing GA (propofol TCI, no NMB) for operative hysteroscopy, Italyall completed
- Participants
- 180 patients
- Comparison
- HFNO vs LMA ventilation for intraoperative respiratory support
- High-flown = 90
- Laryngeal maskn = 90reference
- Primary endpoint
- Intraoperative respiratory support success (SpO2 >94% and transcutaneous CO2 <65 mm Hg with no rescue airway interventions for the entire procedure)
Methodological detailssingle-centre, noninferiority, Italy, May 2022 to June 2023
- Single-centre
- Noninferiority
- Italy, May 2022 to June 2023
Primary result
As reported in the abstract
Absolute difference
0
95% CI 3%
noninferiority P < .001
Events by treatment group
Secondary outcomes
Anesthesia duration
Postoperative respiratory symptoms
P < 0.001
Postoperative dyspnea
- Not different between groups
Safety
| Outcome | High-flow |
|---|---|
| Intraoperative transcutaneous CO2 | |
| Patients with values >55 mm Hg | 43% |
Airway-related complications
- Not different between groups
Intraoperative transcutaneous CO2
- Significantly higher in High-flow
Original publication
High-Flow Nasal Oxygen versus Mechanical Ventilation Through a Laryngeal Mask During General Anesthesia Without Muscle Paralysis: A Randomized Clinical Trial. Anesth Analg. Published 21 July 2025. doi:10.
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