Refining oxygen management through rigorous Oxygen Reserve Index (ORi) monitoring in patients undergoing general anesthesia: a randomized controlled trial : ORi to avoid excessive hyperoxia
Authors' conclusion
Simultaneous ORi and pulse oximetry reduce intraoperative hyperoxemia through safe and meticulous protocol adherence in patients.
Study context
- Population
- Multiple trauma patients, ASA class 3 or higher, undergoing GA51 analysed
- Participants
- 54 patients
- Comparison
- ORi monitoring vs pulse oximetry alone for intraoperative FiO2 titration
- Primary endpoint
- Percentage of normoxemia (80 ≤ PaO2 < 120 mmHg) across ABGAs
Methodological detailssingle-centre, FiO2 adjusted to 0.5 at T0, arterial blood gas analysis (ABGA) every 30 minutes
- Single-centre
- FiO2 adjusted to 0.5 at T0, ABGA every 30 minutes
Primary result
As reported in the abstract
Normoxemia (80 ≤ PaO2 < 120 mmHg)
P = 0.002
Further findings
PaO2 over time · T1–T4
- Baseline PaO2 (T1) comparable within moderate hyperoxemia; at T2 only Group O achieved normoxemia, with consistently lower PaO2 at T2, T3 and T4 vs Group N
ORi values in Group O · T1–T4
- Consistently trended lower from T1 to T4
ORi cut-off values for PaO2 (positive PaO2–ORi correlation)
- ORi cut-off for PaO2 ≥ 120mmHg
- 0.06
- ORi cut-off for PaO2 ≥ 150mmHg
- 0.22
Original publication
Refining oxygen management through rigorous Oxygen Reserve Index (ORi) monitoring in patients undergoing general anesthesia: a randomized controlled trial : ORi to avoid excessive hyperoxia. J Clin Monit Comput. Published 19 July 2025. doi:10.
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