Respiratory failure & ventilation

High‐Flow Tracheal Oxygen for Weaning Mechanically Ventilated Tracheostomized Critically Ill Patients: A Retrospective Study

Acta Anaesthesiol ScandPublished Retrospective cohort study

Authors' conclusion

The timing of HFTO initiation (early vs. rescue) in tracheostomized patients may not have an impact on the rate of liberation from MV at 60 days.

Study context

Population
Mechanically ventilated tracheostomized ICU patients receiving high-flow tracheal oxygen (HFTO) for mechanical ventilation (MV) weaning, 2018–2024
Participants
77 participants
Exposure
Early vs rescue high-flow tracheal oxygen for MV weaning
Outcome
Successful MV liberation from the first successful separation attempt (tolerating ≥ 1 h off MV)
Follow-up
60 days

Main finding

As reported in the abstract

P = 0.679

Observational data: associations, not effects.

Secondary outcomes

VFDs at 60 days · no difference

P = 0.702

Factors associated with successful MV weaning

OR for successful MV weaning (lower odds) (95% CI)
Male genderAssociated with lower odds of successful MV weaning0.24 (0.06–0.88)
HypertensionAssociated with lower odds of successful MV weaning0.24 (0.07–0.82)

Successful MV weaning, overall cohort · 60 days

Successfully weaned from MV at 60 days, all patients
57 (74.0%)

Original publication

High‐Flow Tracheal Oxygen for Weaning Mechanically Ventilated Tracheostomized Critically Ill Patients: A Retrospective Study. Acta Anaesthesiol Scand. Published 11 August 2025. doi:10.1111/aas.70104

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