Haemodynamics, fluids & transfusion
HIgh versus STAndard blood Pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: the HISTAP multicenter randomized clinical trial
Primary resultResult — go to the resultRelative risk 0.78 95% CI 0.65–0.93Authors' conclusion
Among hypertensive patients receiving continuous hemodynamic monitoring and protocolized fluid therapy at increased postoperative risk undergoing major abdominal surgery, targeting an intraoperative MAP ≥ 80 mmHg, compared with ≥ 65 mmHg, reduced major organ dysfunction, primarily due to fewer mild-to-moderate acute kidney injuries.
Study context
- Population
- Patients aged ≥ 60 years with chronic hypertension requiring home therapy, undergoing elective major abdominal surgery with at least one additional high-risk criterion; 18 Italian centres, March 2023–April 2025630 analysed (ITT)
- Participants
- 636 patients
- Comparison
- Intraoperative mean arterial pressure (MAP) target ≥ 80 vs ≥ 65 mmHg
- Primary endpoint
- Composite of:
- Postoperative mortality
- At least one major organ dysfunction
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Relative risk
0.78
95% CI 0.65–0.93
P = 0.006
By group
Treatment vs Control
RR 0.78 (95% CI 0.65–0.93); P = 0.006
Further findings
Mean intraoperative MAP
AKI · significantly less frequent in the Treatment group
P = 0.005
Original publication
HIgh versus STAndard blood Pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: the HISTAP multicenter randomized clinical trial. Intensive Care Med. Published 29 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →