Respiratory failure & ventilation
Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort
Authors' conclusion
ICU mortality in COVID-19 patients was associated with higher dp-ucMGP levels over 4 weeks, independent of age, gender, and APACHE II score, and not explained by inflammation, renal function, history of coumarin use, and CAC score.
Study context
- Population
- Intensive care unit (ICU) patients with confirmed COVID-19 undergoing endotracheal intubation (ETI) (Maastricht Intensive Care COVID cohort)
- Participants
- 112 patients
- Exposure
- ICU non-survivors vs ICU survivors
- Outcome
- Association of dp-ucMGP at ETI with ICU and six months mortality
Methodological detailsserial measurements
- Serial measurements
Main finding
As reported in the abstract
ICU and six months mortality per 100 pmol/L dp-ucMGP at ETI · at ETI
Per 100 pmol/L dp-ucMGPOdds ratio (95% CI)P value
ICU mortality
1.056(0.977–1.141)
P = 0.172Six months mortality
1.059(0.976–1.059)
P = 0.170Per 100 pmol/L dp-ucMGP, as printed
Observational data: associations, not effects.
Further findings
| Outcome | Difference (pmol/L) (95% CI) | P value | |
|---|---|---|---|
| Plasma dp-ucMGP over time of ICU admission (serial, 4 weeks after ETI)Additionally adjusted for CAC score | 213 (3–422) | P = 0.051 | |
| −2000200400600Difference, pmol/L (linear scale) |
pmol/L
- Plasma dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) over time of ICU admission (serial, 4 weeks after ETI) — Mean difference in plasma dp-ucMGP over time of ICU admission, adjusted for age, gender, APACHE II score
- 167 (95% CI: 4 to 332, p = 0.047)
- Plasma dp-ucMGP over time of ICU admission (serial, 4 weeks after ETI) — Difference after additional adjustment for C-reactive protein, creatinine, history of coumarin use
- 199 (95% CI: 50 to 346, p = 0.010)
Plasma dp-ucMGP over time of ICU admission (serial, 4 weeks after ETI)
- Regression slope (changes over time) did not differ
Pulmonary embolism (PE)
- dp-ucMGP not associated with PE
Original publication
Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort. J Intensive Care. Published 18 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →