Cardiac arrest & resuscitation
Hospital Variation in Epinephrine Administration Before Defibrillation for Cardiac Arrest Due to Shockable Rhythm*
Authors' conclusion
Hospital rates of epinephrine administration before defibrillation were associated with a significant stepwise decrease in hospital rates of risk-adjusted survival.
Study context
- Population
- Adults with in-hospital cardiac arrest (IHCA) due to an initial shockable rhythm, 513 hospitals in the Get With The Guidelines Resuscitation Registry, 2000–2019
- Participants
- 37,668 adults · 513 hospitals
- Exposure
- Hospitals by quartile of rate of epinephrine before first defibrillation
- Outcome
- Hospital variation in rates of epinephrine administration before defibrillation and its association with hospital-level risk-adjusted survival
Methodological detailsmultivariable hierarchical regression, multicentre registry
- Multivariable hierarchical regression
- Multicentre registry
Main finding
As reported in the abstract
P for trend < 0.001
- Median hospital rate of epinephrine before defibrillation
- 18.8%
- Range across sites
- 0-68.8%
- Median OR
- 1.54 (95% CI, 1.47-1.61)
Observational data: associations, not effects.
Further findings
Hospital factors associated with rate of epinephrine before defibrillation
- Major teaching status and annual IHCA volume associated with hospital rate
Original publication
Hospital Variation in Epinephrine Administration Before Defibrillation for Cardiac Arrest Due to Shockable Rhythm*. Crit Care Med. Published 7 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →