Neuroanesthesia & neurocritical care
Hypotension and Adverse Outcomes in Moderate to Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis
Authors' conclusion
This meta-analysis of nearly 400 000 patients with TBI found a significant association of greater than 2-fold odds of mortality in patients with hypotension and TBI.
Study context
- Population
- Patients aged at least 10 years with moderate to severe traumatic brain injury (TBI)
- Participants
- 384,329 patients · 51 studies
- Comparison
- Hypotension vs no hypotension
- Outcome
- Association of hypotension with death and/or vegetative state; incidence of hypotension
- Follow-up
- 6 months
Methodological detailsrandom-effects model, PRISMA and MOOSE reporting
- Random-effects model
- PRISMA and MOOSE reporting
Pooled result
As reported in the abstract
Mortality
Hypotension vs No hypotensionEstimate (95% CI)P value
I2 = 96.98%
crude OR 3.82(3.04–4.81)
P < 0.001I2 = 92.21%
adjusted OR 2.22(1.96–2.51)
P < 0.001Further pooled results
Overall hypotension incidence
- Hypotension incidence
- 18% (95% CI, 12%-26%; P < .001; I2 = 99.84%)
Original publication
Hypotension and Adverse Outcomes in Moderate to Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. JAMA Netw Open. Published 4 November 2024. doi:10.
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