Neuroanesthesia & neurocritical care
Hypotension during transsphenoidal pituitary surgery associated with increase in plasma levels of brain injury markers
Authors' conclusion
Intraoperative relative, but not absolute, hypotension was associated with increased postoperative plasma tau and NfL concentrations.
Study context
- Population
- Patients undergoing transsphenoidal pituitary surgery, Gothenburg Pituitary Tumor Study, June 2016–October 2017
- Participants
- 35 patients
- Exposure
- Intraoperative hypotension vs postoperative plasma brain injury markers
- Outcome
- Difference between highest postoperative and preoperative plasma tau, NfL and GFAP (∆taupeak, ∆NfLpeak, ∆GFAPpeak)
Main finding
As reported in the abstract
Association of intraoperative hypotension with ∆taupeak, ∆NfLpeak, ∆GFAPpeak
Positive correlation between AUC20% and ∆taupeak (r2)
r2 = .20
p < .001
Positive correlation between AUC20% and ∆NfLpeak (r2)
r2 = .26
p < .001
Observational data: associations, not effects.
Further findings
Time course of plasma markers
- Plasma tau and glial fibrillary acidic protein (GFAP) highest immediately after surgery and on day 1; Neurofilament light (NfL) highest on day 5
Original publication
Hypotension during transsphenoidal pituitary surgery associated with increase in plasma levels of brain injury markers. Acta Anaesthesiol Scand. Published 3 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →