Cardiothoracic & vascular anesthesia
The role of blood pressure versus oxygen administration on cerebral oxygenation during and after anaesthesia induction: A prospective cohort study
Authors' conclusion
Changes in regional cerebral tissue oximetry during and after anaesthesia induction are more related to changes in oxygen administration than blood pressure.
Study context
- Population
- Elective cardiac surgery patients, Dutch tertiary hospital, October 2019 to May 2022188 analysed
- Participants
- 251 patients
- Exposure
- Changes in mean arterial pressure (MAP) vs oxygen administration (PetO2, FiO2) in relation to cerebral oxygenation; with vs without postinduction hypotension
- Outcome
- Continuous cerebral oxygenation (near-infrared spectroscopy (NIRS)-based regional cerebral tissue oximetry) in relation to MAP, PetO2 and FiO2 during and after anaesthesia induction
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Onset of decline in cerebral oxygenation after induction coincided with FiO2 change from high to low and preceded decline in MAP
16.4
s; 95% CI 2.4 to 30.4P = 0.02
Increase in cerebral oxygenation per percentage point increase in PetO2 during induction with FiO2 1.0
0.14%
95% CI 0.12 to 0.16P < 0.001
Observational data: associations, not effects.
Further findings
Cerebral oxygenation by postinduction hypotension (PIH) (subgroup)
- PIH occurred in 42% of the study population and did not affect cerebral oxygenation
Original publication
The role of blood pressure versus oxygen administration on cerebral oxygenation during and after anaesthesia induction: A prospective cohort study. Eur J Anaesthesiol. Published 6 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →