Hemodynamics, fluids & transfusion
Hypotension Prediction Index guided Goal Directed therapy and the amount of Hypotension during Major Gynaecologic Oncologic Surgery: a Randomized Controlled clinical Trial
Authors' conclusion
Compared to a GDT protocol aimed to SVI optimization, a machine learning-derived algorithm for prediction of IOH combined with a GDT hemodynamic protocol, reduced IOH and hypotension after induction of general anesthesia in patients undergoing major gynaecologic oncologic surgery.
Study context
- Population
- Women scheduled for major gynaecologic oncologic surgery under GA with invasive arterial pressure monitoring10 excluded
- Participants
- 60 women
- Comparison
- Hypotension Prediction Index (HPI) guidance plus Goal Directed Therapy (GDT) vs GDT protocol aimed at stroke volume index (SVI) optimisation
- HPIn = 30
- Controln = 30reference
- Primary endpoint
- Amount of intraoperative hypotension: time-weighted average (timeweighted average (TWA)) mean arterial pressure (MAP) < 65 mmHg
Primary result
As reported in the abstract
TWA-MAP < 65 mmHg
P < 0.001
Secondary outcomes
TWA-MAP < 65 mmHg during first 20 min after induction of GA
P = 0.001
Original publication
Hypotension Prediction Index guided Goal Directed therapy and the amount of Hypotension during Major Gynaecologic Oncologic Surgery: a Randomized Controlled clinical Trial. J Clin Monit Comput. Published 29 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →