Hypothermia for expanded criteria organ donors in kidney transplantation in France (HYPOREME): a multicentre, randomised controlled trial
Authors' conclusion
Hypothermia in expanded criteria donors whose organs were routinely stored using machine perfusion did not decrease the frequency of delayed kidney graft function. However, hypothermia was associated with a lower serum creatinine concentration and a higher creatinine clearance 1 year after transplantation.
Study context
- Population
- Expanded criteria brain-dead donors (>60 y, or 50–59 y with ≥2 risk factors) and their kidney graft recipients, 53 ICUs and transplant centres in France
- Participants
- 526 recipients
- Comparison
- Donor hypothermia vs normothermia
- Hypothermian = 251
- Normothermian = 275reference
- Primary endpoint
- Delayed graft function (RRT within 7 days after transplantation) in kidney recipients
- Follow-up
- 7 days
Methodological detailsmulticentre, parallel-arm, masked outcome assessors, machine perfusion used routinely
- Multicentre
- Parallel-arm
- Masked outcome assessors
- Machine perfusion used routinely
Primary result
As reported in the abstract
Delayed graft function
Each group vs normothermiaOdds ratio (95% CI)P value
Hypothermia
0.71(0.44–1.13)
P = 0.14- Hypothermia
- absolute difference −5.2% (95% CI 11.8–1.5)
Secondary outcomes
Donor highest MAP
P = 0.001
Recipient creatinine concentration · 1 year
P = 0.0351
Recipient creatinine clearance · 1 year
P = 0.0414
Other secondary outcomes
- No significant differences between groups
Original publication
Hypothermia for expanded criteria organ donors in kidney transplantation in France (HYPOREME): a multicentre, randomised controlled trial. Lancet Respir Med. Published 11 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →