ICU sedation, delirium & recovery
ICU- and ventilator-free days with isoflurane or propofol as a primary sedative – A post- hoc analysis of a randomized controlled trial
Authors' conclusion
Isoflurane via the ACD was not associated with more VFD but with more ICU-FD and less concomitant sedative use.
Study context
- Population
- ICU patients from an randomized controlled trial (RCT) of isoflurane vs propofol sedation with 30-day follow-up data and no conversion to the other drug
- Participants
- 69 vs 109
- Comparison
- Inhaled isoflurane via Sedaconda anaesthetic conserving device (ACD) vs intravenous propofol
- Isofluranen = 69
- Propofoln = 109reference
- Primary endpoint
- ICU-free days (ICU-FD) and ventilator-free days (VFD)
- Follow-up
- 30 days after randomization
Methodological detailsadjusted for potential confounders
- Adjusted for potential confounders
Primary result
As reported in the abstract
ICU-free days (adjusted) · 30 days
P = 0.028
Further findings
| Outcome | Isoflurane | Propofol | P value |
|---|---|---|---|
| Ventilator-free days · 30 days | 19.8 | 18.5 | P = 0.454 |
| Concomitant use of other sedatives | P < 0.0001 |
Concomitant use of other sedatives
- Other sedatives used more frequently in the propofol group
Safety
| Outcome | P value |
|---|---|
| RRT started | P = 0.011 |
Renal replacement therapy (RRT) started
- RRT started in a greater proportion of patients in the propofol group
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
ICU- and ventilator-free days with isoflurane or propofol as a primary sedative – A post- hoc analysis of a randomized controlled trial. J Crit Care. Published 14 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →