Identification of Clinically Significant Cytokine Signature Clusters in Patients With Septic Shock
Authors' conclusion
Longitudinal measurement of cytokine profiles at initiation of vasoactive medications and 24 hours later revealed three distinct cytokine signature clusters that correlated with clinical outcomes.
Study context
- Population
- Adults (≥ 18 yr) admitted to the medical ICU with septic shock requiring vasoactive medication support, single US academic centercompleted cytokine measurement
- Participants
- 114 adults
- Exposure
- Cytokine signature clusters 2 and 3 vs cluster 1
- Outcome
- Mortality by cluster
Methodological detailssingle-centre, unsupervised random forest analysis
- Single-centre
- Unsupervised random forest analysis
Main finding
As reported in the abstract
Each group vs cluster 1Odds ratio (CI)
Cluster 2
3.56(1.10–14.23)
Cluster 3
9.23(2.89–37.22)
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| In-hospital mortality, multivariable analysisCluster 3 vs Cluster 1 · independently associated · multivariable analysis | 5.24 | P = 0.005 |
Initial clinical severity scoring and steroid use
- No significant differences between the clusters
Clustering on t 1 or t 2 cytokines alone or combined
- Did not reveal clusters with clear clinical significance
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Identification of Clinically Significant Cytokine Signature Clusters in Patients With Septic Shock. Crit Care Med. Published 5 September 2023. doi:10.
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