Identifying high-risk phenotypes and associated harms of delayed time-to-antibiotics in patients with Intensive Care Unit (ICU) onset sepsis: A retrospective cohort study
Authors' conclusion
Septic patients with respiratory or cardiovascular dysfunction were associated with harms of delayed time-to-antibiotics.
Study context
- Population
- Patients with ICU onset sepsis, Medical Information Mart for Intensive Care IV (MIMIC-IV) databasein final analysis
- Participants
- 6,246 patients
- Exposure
- Delayed vs earlier time-to-antibiotics, by sepsis phenotype
- Outcome
- Mortality
- Follow-up
- 28 days
Methodological detailslatent profile analysis, MIMIC-IV database
- Latent profile analysis
- MIMIC-IV database
Main finding
As reported in the abstract
28-day mortality per delayed time-to-antibiotics
Estimate (95% CI)
Delayed time-to-antibioticsall patients
HR 1.12(1.08–1.18)
Phenotype 1delayed time-to-antibiotics
adjusted HR 1.16(1.08–1.25)
Phenotype 2delayed time-to-antibiotics
adjusted HR 1.06(1.00–1.13)
Per delayed time-to-antibiotics, as printed
Observational data: associations, not effects.
Further findings
- Overall 28-day mortality
- 12.7%
Original publication
Identifying high-risk phenotypes and associated harms of delayed time-to-antibiotics in patients with ICU onset sepsis: A retrospective cohort study. J Crit Care. Published 22 December 2022. doi:10.
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