Clinical phenotyping of septic shock with latent profile analysis: A retrospective multicenter study
Authors' conclusion
The three SS phenotypes differed significantly in pathophysiological and clinical outcomes, which are crucial for informing management decisions and prognosis.
Study context
- Population
- Patients with septic shock in the MIMIC cohort; validation in eICU and AUMC cohorts
- Exposure
- Phenotype I vs Phenotype II vs Phenotype III
- Outcome
- Clinical phenotypes of septic shock
Methodological detailsmulticentre, latent profile analysis, external validation, latent profile analysis (LPA) derivation in MIMIC; external validation in eICU and AUMC
- Multicentre
- Latent profile analysis
- External validation
- LPA derivation in MIMIC; external validation in eICU and AUMC
Main finding
As reported in the abstract
- Phenotype I had the highest mortality
- p < 0.001
Observational data: associations, not effects.
Further findings
Survival over time
- Phenotype I had the steepest survival curves and ultra-high risk of death, particularly within the first few days after septic shock (SS) onset
Original publication
Clinical phenotyping of septic shock with latent profile analysis: A retrospective multicenter study. J Crit Care. Published 20 October 2024. doi:10.
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