Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes
Authors' conclusion
Our research underscores the reproducibility of latent profile analyses to identify pediatric septic shock phenotypes with high prognostic relevance.
Study context
- Population
- Pediatric septic shock patients requiring vasoactive support on day 1
- Participants
- 1,071 patients
- Comparison
- Phenotype 1 vs Phenotype 2
- Primary endpoint
- Complicated course
Methodological detailslatent profile analysis, support vector machine assignment in internal validation set, transcriptomic analysis
- Latent profile analysis
- Support vector machine assignment in internal validation set
- Transcriptomic analysis
Primary result
As reported in the abstract
Further findings
Interaction of phenotypes with common sepsis treatments on outcomes
- No significant interactions between phenotypes, common treatments and clinical outcomes
Transcriptomics
- Phenotype 1: overexpression of innate immune response genes, driven primarily by developing neutrophils
Overlap with established gene-expression endotypes
- No statistically significant overlap with the new phenotypes
- Integrated subclassification scheme showed varying survival probabilities across endophenotypes
Original publication
Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes. Crit Care. Published 17 July 2024. doi:10.
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