Airway management

Immediate “sipping” vs. delayed oral fluid intake after extubation: A randomized controlled trial

J Crit CarePublished Randomised controlled trial

Primary result · ThirstResult — go to the resultDifference 0.0 % 95% CI −12 % to 12 %

Authors' conclusion

Immediate oral fluid intake "sipping"after extubation appears to be safe, improves thirst relief, and reduces discomfort in ICU patients without increasing adverse effects.

Study context

Population
ICU patients who met extubation criteria
Participants
160 patients
Comparison
Immediate sipping vs delayed oral fluid intake
  • Sippingn = 80
  • Standardn = 80reference
Primary endpoint
Thirst
Follow-up
120 min
Methodological detailssingle-center, prospective, 1:1 randomization
  • Single-center
  • Prospective
  • 1:1 randomization

Primary result

As reported in the abstract

Difference

0.0 %

95% CI −12 % to 12 %

P = 1.000

Events by treatment group

Sipping vs Standard
difference 0.0 % (95% CI −12 % to 12 %); P = 1.000

Further findings

%

OutcomeSippingStandardDifference (95% CI)P value
Thirst relief between baseline and 120 min11.3 (95% CI 5-20 %)1.3 (95% CI 0-7 %)10 % (1-19 %)P = 0.0338
Throat discomfort · 90 min23.8 (95% CI 15-35 %)42.5 (95% CI 32-54 %)−18.7 % (−34 % to −3 %)P = 0.0118

Safety

Adverse effects (nausea, vomiting, aspiration)

Aspiration events
0
Nausea, vomiting rare and comparable

Original publication

Immediate “sipping” vs. delayed oral fluid intake after extubation: A randomized controlled trial. J Crit Care. Published 7 August 2025. doi:10.1016/j.jcrc.2025.155212

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