Immediate “sipping” vs. delayed oral fluid intake after extubation: A randomized controlled trial
Primary result · ThirstResult — go to the resultDifference 0.0 % 95% CI −12 % to 12 %Authors' conclusion
Immediate oral fluid intake "sipping"after extubation appears to be safe, improves thirst relief, and reduces discomfort in ICU patients without increasing adverse effects.
Study context
- Population
- ICU patients who met extubation criteria
- Participants
- 160 patients
- Comparison
- Immediate sipping vs delayed oral fluid intake
- Sippingn = 80
- Standardn = 80reference
- Primary endpoint
- Thirst
- Follow-up
- 120 min
Methodological detailssingle-center, prospective, 1:1 randomization
- Single-center
- Prospective
- 1:1 randomization
Primary result
As reported in the abstract
Difference
0.0 %
95% CI −12 % to 12 %
P = 1.000
Events by treatment group
Sipping vs Standard
difference 0.0 % (95% CI −12 % to 12 %); P = 1.000
Further findings
%
| Outcome | Sipping | Standard | Difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Thirst relief between baseline and 120 min | 11.3 (95% CI 5-20 %) | 1.3 (95% CI 0-7 %) | 10 % (1-19 %) | P = 0.0338 | |
| Throat discomfort · 90 min | 23.8 (95% CI 15-35 %) | 42.5 (95% CI 32-54 %) | −18.7 % (−34 % to −3 %) | P = 0.0118 | |
| −40−20020Difference (linear scale) |
Safety
Adverse effects (nausea, vomiting, aspiration)
- Aspiration events
- 0
- Nausea, vomiting rare and comparable
Original publication
Immediate “sipping” vs. delayed oral fluid intake after extubation: A randomized controlled trial. J Crit Care. Published 7 August 2025. doi:10. 1016/ j. jcrc. 2025. 155212
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