Cardiac arrest & resuscitation
Impact of differential temperature trajectories following targeted temperature management on outcomes in out-of-hospital cardiac arrest patients receiving extracorporeal cardiopulmonary resuscitation (ECPR): a multicenter, retrospective study with prospective validation
Main finding · 90-day mortalityResult — go to the resultHazard ratio 2.63 95 % CI 1.81–3.81Authors' conclusion
Among OHCA patients treated with ECPR and TTM, a high temperature variability pattern temperatures recorded between 48 and 72 h is associated with lower 90-day mortality and improved neurological outcomes.
Study context
- Population
- Adults with witnessed out-of-hospital cardiac arrest (OHCA) treated with ECPR and standardized targeted temperature management (TTM), 6 intensive care units (ICUs) in Zhejiang Province, 2017–2023
- Participants
- 107 vs 170
- Exposure
- High vs low temperature variability after TTM
- High-temperature variability group (HTVG)n = 107
- Low-temperature variability group (LTVG)n = 170reference
- Outcome
- 90-day mortality
- Follow-up
- 90 days
Methodological detailsmulticentre, prospective validation cohort
- Multicentre
- Prospective validation cohort
Main finding
As reported in the abstract
Hazard ratio
2.63
95 % CI 1.81–3.81
log-rank p < 0.001
By group
LTVG vs HTVG
HR 2.63 (95 % CI 1.81–3.81); log-rank p < 0.001
Observational data: associations, not effects.
Secondary outcomes
Poor neurological outcome (mRS 4-6)
P < 0.001
Safety
Moderate or severe bleeding
P = 0.005
Original publication
Impact of differential temperature trajectories following targeted temperature management on outcomes in out-of-hospital cardiac arrest patients receiving ECPR: a multicenter, retrospective study with prospective validation. Resuscitation. Published 22 December 2025. doi:10.
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