Respiratory failure & ventilation
The impact of a lung-protective ventilation mode using transpulmonary driving pressure titrated positive end-expiratory pressure on the prognosis of patients with acute respiratory distress syndrome
Authors' conclusion
Lung-protective mechanical ventilation using transpulmonary driving pressure titrated PEEP effectively improves lung function, reduces mechanical ventilation duration and hospital stay, and enhances survival outcomes in patients with ARDS.
Study context
- Population
- Patients with Acute Respiratory Distress Syndrome (ARDS)
- Participants
- 105 patients
- Comparison
- Study vs Control
- Studyn = 53
- Controln = 51reference
- Primary endpoint
- Prognosis: mechanical ventilation duration, hospital stay, 28-day mortality, VAP incidence, survival outcome
Primary result
As reported in the abstract
Mechanical ventilation duration, hospital stay, 28-day mortality, VAP
- Significantly shorter mechanical ventilation duration and hospital stay in the study group
- No significant differences in 28-day mortality and ventilator-associated pneumonia (VAP) incidence
Further findings
PaCO2 · after 48 h of mechanical ventilation · not statistically significant
P > 0.05
| Outcome | HR for death (95% CI) | |
|---|---|---|
| Survival (Kaplan-Meier) · 60-day follow-upSignificantly better survival in the Study group | 0.565 (0.320–0.999) | |
| 0.20.5125HR for death (log scale) |
- PaCO2: Study group PaCO2 rose significantly from pre-intervention 34.19 ± 5.39 mmHg
PaO2 and oxygenation index (OI) · after 48 h of mechanical ventilation
- Significantly higher PaO2 and OI in the Study vs the Control group
- all P < 0.05
Hemodynamic indicators (heart rate, MAP, central venous pressure) · post-intervention
- No significant differences between the two groups
- all P > 0.05
MV duration and hospital LOS
- Significantly shorter MV duration and hospital stay in the Study group
28-day mortality and VAP incidence
- No significant differences
Original publication
The impact of a lung-protective ventilation mode using transpulmonary driving pressure titrated positive end-expiratory pressure on the prognosis of patients with acute respiratory distress syndrome. J Clin Monit Comput. Published 19 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →