Cardiothoracic & vascular anesthesia
The effect of driving pressure-guided versus conventional mechanical ventilation strategy on pulmonary complications following on-pump cardiac surgery: A randomized clinical trial
Primary resultResult — go to the resultRelative risk 0.99 95% CI 0.82–1.18Authors' conclusion
Among patients who underwent on-pump cardiac surgery, the use of driving pressure-guided ventilation strategy did not reduce the risk of postoperative pulmonary complications when compared with conventional lung-protective ventilation strategy.
Study context
- Population
- Adults scheduled for elective on-pump cardiac surgery, West China university hospital, Sichuan, Chinaincluded in final analysis
- Participants
- 694 adults
- Comparison
- Driving pressure vs Conventional
- Primary endpoint
- Pulmonary complications (ARDS, atelectasis, pneumonia, pleural effusion, pneumothorax)
- Follow-up
- First 7 postoperative days
Methodological detailsprospective, two-arm, single-centre, Enrolment August 2020 to July 2021
- Prospective
- Two-arm
- Single-centre
- Enrolment August 2020 to July 2021
Primary result
As reported in the abstract
Relative risk
0.99
95% CI 0.82–1.18
P = 0.877
Events by treatment group
Driving pressure vs Conventional
RR 0.99 (95% CI 0.82–1.18); P = 0.877
Secondary outcomes
| Outcome | Driving pressure | Conventional | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Atelectasis | 11.5% | 17.0% | 0.68 (0.47–0.98) | P = 0.039 | |
| 0.512Relative risk (log scale) |
Pulmonary complication severity, ICU LOS, in-hospital and 30-day mortality
- Did not differ between groups
Original publication
The effect of driving pressure-guided versus conventional mechanical ventilation strategy on pulmonary complications following on-pump cardiac surgery: A randomized clinical trial. J Clin Anesth. Published 10 June 2023. doi:10.
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