Pediatric anesthesia & critical care
Impact of the Magnitude and Timing of Fluid Overload on Outcomes in Critically Ill Children: A Report From the Multicenter International Assessment of Worldwide Acute Kidney Injury, Renal Angina, and Epidemiology (AWARE) Study
Authors' conclusion
This study found that mild-to-moderate FO as early as at the end of ICU Day1 is associated with adverse outcomes.
Study context
- Population
- Children and young adults admitted consecutively to pediatric ICUs (AWARE study)
- Participants
- 5,079 children
- Exposure
- Fluid overload (FO) ≥ 5% and FO ≥ 10% at end of ICU days 1 and 2
- FO ≥ 5%Day1n = 1,753
- FO ≥ 10%Day1n = 537
- FO ≥ 5%Day2n = 1,539
- FO ≥ 10%Day2n = 724
- Outcome
- Frequency of FO thresholds
Methodological detailsmulticentre, international, 32 pediatric ICUs
- Multicentre
- International
- 32 pediatric ICUs
Main finding
As reported in the abstract
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of the Magnitude and Timing of Fluid Overload on Outcomes in Critically Ill Children: A Report From the Multicenter International Assessment of Worldwide Acute Kidney Injury, Renal Angina, and Epidemiology (AWARE) Study. Crit Care Med. Published 17 February 2023. doi:10.
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