Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry
Authors' conclusion
Inability to liberate from CRRT was common in this multinational retrospective study. Modifiable and non-modifiable factors were associated with successful liberation.
Study context
- Population
- Children and young adults (aged 0–25 years) treated with continuous renal replacement therapy (CRRT) for acute kidney injury (AKI) or fluid balance (FB) disorders, 32 centers, 7 nations, 2015 to 2021
- Participants
- 622 children · 32 centers
- Exposure
- Success vs Reinstituted
- Successn = 335
- Reinstitutedn = 287reference
- Outcome
- Factors associated with successful CRRT liberation
Methodological detailsmulticentre, international, multivariable logistic regression
- Multicentre
- International
- Multivariable logistic regression
Main finding
As reported in the abstract
Odds of successful CRRT liberation (no dialysis for ≥ 72 h after first liberation attempt), multivariable logistic regression
OR of successful liberation (CI)
Higher VIS at CRRT initiation
1.35(1.12–1.63)
Higher PELOD-2 score at CRRT initiation
1.71(1.24–2.35)
Shorter CRRT duration
0.19(0.12–0.28)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry. Intensive Care Med. Published 4 March 2024. doi:10.
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