Pediatric anesthesia & critical care
Net Fluid Balance Impacts Pediatric Continuous Renal Replacement Therapy Liberation
Authors' conclusion
Patients with a more positive NFB had fewer CRRT-free days. Preservation of UOP was associated with more CRRT-free days.
Study context
- Population
- Children and young adults receiving continuous renal replacement therapy (CRRT) at two quaternary pediatric hospitals, 2/2014–2/2020
- Participants
- 371 children
- Exposure
- Net fluid balance on CRRT as predictor of renal recovery
- Outcome
- NFB on CRRT and outcomes
Methodological detailstwo-centre, Two quaternary PICUs
- Two-centre
- Two quaternary PICUs
Main finding
As reported in the abstract
- Net fluid balance (NFB) between −4.46 and −0.305 mL/kg/hr associated with more CRRT-free days (β)
- 2.90 [0.24-5.56]
- NFB between −4.46 and −0.305 mL/kg/hr associated with decreased odds of MAKE-30 (aOR)
- 0.41 [0.22-0.79]
- Median NFB day 1 (mL/kg/hr)
- 0.33 (−0.43 to 1.18)
- Median NFB day 2 (mL/kg/hr)
- −0.14 (−0.72 to 0.52)
- Median NFB day 3 (mL/kg/hr)
- −0.24 (−0.85 to 0.42)
Observational data: associations, not effects.
Further findings
Preserved urine output (UOP) >0.3 mL/kg/hr
- More CRRT-free days
- 5.6
- Decreased odds of MAKE-30
Original publication
Net Fluid Balance Impacts Pediatric Continuous Renal Replacement Therapy Liberation. Crit Care Med. Published 18 March 2025. doi:10.
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