Major Adverse Kidney Events in Pediatric Continuous Kidney Replacement Therapy
Authors' conclusion
In this study, MAKE-90 occurred in almost two-thirds of the population and patient-level risk factors associated with MAKE-90 included cardiac comorbidity, time to CKRT initiation, and liberation patterns.
Study context
- Population
- Patients aged 0 to 25 years treated with continuous kidney replacement therapy (CKRT) for AKI or fluid overload, WE-ROCK registry, 2015 to 2021; excluding dialysis dependence, concurrent ECMO or CKRT for another indication
- Participants
- 969 patients
- Exposure
- CKRT liberation patterns: successful vs reinstituted vs not attempted
- Outcome
- MAKE-90: death or persistent kidney dysfunction (dialysis dependence or ≥25% decline in eGFR from baseline)
- Follow-up
- 90 days after CKRT initiation
Methodological detailsinternational, registry
- International
- Registry
Main finding
As reported in the abstract
MAKE-90 (death or persistent kidney dysfunction)
Adjusted odds ratio (95% CI)
Successful liberation vs Liberation attempted and failed
0.32(0.22–0.48)
Successful liberation vs No liberation attempt
0.02(0.01–0.04)
Cardiac comorbidity
1.60(1.08–2.37)
- Incidence of MAKE-90 among 969 patients treated with CKRT
- 630 (65.0%)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Risk factors for MAKE-90 (multivariable analysis)ICU admission before CKRT initiation, 6 days vs 1 day | 1.07 (1.02–1.13) | |
| Risk factors for MAKE-90 (multivariable analysis)Successful liberation vs Reinstituted | 0.32 (0.22–0.48) | |
| Risk factors for MAKE-90 (multivariable analysis)Successful liberation vs Not attempted | 0.02 (0.01–0.04) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Major Adverse Kidney Events in Pediatric Continuous Kidney Replacement Therapy. JAMA Netw Open. Published 5 February 2024. doi:10.
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