Prognostic associations of urine output in acute kidney injury (AKI) and dialysis vintage in end-stage kidney disease (ESKD) at continuous kidney replacement therapy initiation in ICU patients
Authors' conclusion
In ICU patients starting CKRT, pre-CKRT urine output in AKI and dialysis vintage in ESKD were associated with short-term prognosis. Non-oliguric AKI was associated with a lower adjusted hazard of death than ESKD, and longer dialysis vintage was associated with a higher hazard of death within ESKD.
Study context
- Population
- Consecutive adults starting continuous kidney replacement therapy (CKRT) in a combined medical-surgical ICU, 2012–2021
- Participants
- 560 adults
- Exposure
- Oliguric AKI and non-oliguric AKI vs ESKD at CKRT initiation; dialysis vintage within ESKD
- ESKDn = 66reference
- Oliguric AKIn = 305
- Non-oliguric AKIn = 189
- Outcome
- Time to all-cause death
- Follow-up
- 90 days after CKRT initiation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Death within 90 days · 90 days
Each group vs ESKDAdjusted hazard ratio (95% CI)
Oliguric AKInot associated with a different hazard
0.86(0.58–1.29)
Non-oliguric AKIlower hazard
0.63(0.41–0.99)
- Documented death within 90 days, all patients
- 236 (42.1%)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Death within 90 days by dialysis vintage (ESKD subgroup)Adjusted for APACHE II score and sepsis | 1.07 (1.02–1.11) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Prognostic associations of urine output in AKI and dialysis vintage in ESKD at continuous kidney replacement therapy initiation in ICU patients. J Intensive Care. Published 16 August 2026. doi:10.
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