Time to Continuous Renal Replacement Therapy Initiation and 90-Day Major Adverse Kidney Events in Children and Young Adults
Main finding · MAKE-90Result — go to the resultOdds ratio 1.03 95% CI 1.02–1.04Authors' conclusion
In this cohort study of children and young adults receiving CRRT, longer time to CRRT initiation was associated with greater risk of MAKE-90 outcomes, in particular, mortality.
Study context
- Population
- Children and young adults (birth to 25 years) receiving continuous renal replacement therapy (CRRT) for AKI or volume overload at 32 centers across 7 countries, WE-ROCK registry, 2015–2021after 27 exclusions
- Participants
- 969 children
- Exposure
- Time to CRRT initiation from ICU admission
- MAKE-90n = 630
- Outcome
- MAKE-90 (death, dialysis dependence, or persistent kidney dysfunction [>25% decline in eGFR from baseline])
- Follow-up
- 90 days
Methodological detailsmultinational, multicentre registry, generalized propensity score-weighted, Statistical analysis February to July 2023
- Multinational
- Multicentre registry
- Generalized propensity score-weighted
- Statistical analysis February to July 2023
Main finding
MAKE-90
Odds ratio
1.03
95% CI 1.02–1.04
By group
Each 1-day delay in CRRT initiation
OR 1.03 (95% CI 1.02–1.04)
Each 1-day delay in CRRT initiation, as printed
As reported in the abstract
- MAKE-90 occurred
- 630 (65.0%)
- Died (of MAKE-90)
- 368 (58.4%)
- Persistent kidney dysfunction among 601 survivors
- 262 (43.6%)
- Dialysis dependent among those with persistent dysfunction
- 91 (34.7%)
- Median (IQR) time to CRRT initiation, all
- 2 (1-6) days
Observational data: associations, not effects.
Original publication
Time to Continuous Renal Replacement Therapy Initiation and 90-Day Major Adverse Kidney Events in Children and Young Adults. JAMA Netw Open. Published 2 January 2024. doi:10.
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