Factors associated with adverse haemodynamic events during the STARRT-AKI trial: a post-hoc secondary analysis
Authors' conclusion
In this secondary analysis of the STARRT-AKI trial, the use of intermittent RRT modalities and higher severity of illness were associated with HAE during RRT. These events were not significantly associated with adverse clinical outcomes, apart from a significant association between multiple HAE and all-cause mortality at 90 days.
Study context
- Population
- ICU patients receiving RRT in the STARRT-AKI trial
- Comparison
- Risk factors for haemodynamic adverse events (HAE) during RRT; initial RRT modality intermittent haemodialysis (IHD) or sustained low efficiency dialysis (SLED) vs continuous renal replacement therapy (CRRT)
- Primary endpoint
- Time to HAE (dependent variable of the primary analysis: multivariable Cox proportional hazards model based on LASSO)
Methodological detailspost-hoc, multinational, multivariable Cox proportional hazards model (least absolute shrinkage and selection operator (LASSO))
- Post-hoc
- Multinational
- Multivariable Cox proportional hazards model (LASSO)
Primary result
As reported in the abstract
Factors associated with HAE during RRT
Hazard ratio (95% CI)
Higher SOFA score at RRT initiation
1.05(1.00–1.10)
IHD vs CRRT
1.74(1.28–2.37)
SLED vs CRRT
2.73(1.65–4.51)
Further findings
Association of HAE with clinical outcomes (mortality, dialysis dependence, LOS, RRT-, ventilator- and vasoactive-free days)
- No significant association between HAE and these outcomes (adjusted multivariable analysis)
Multiple HAE and all-cause mortality · 90 days
- Significant association between multiple HAE and all-cause mortality
Original publication
Factors associated with adverse haemodynamic events during the STARRT-AKI trial: a post-hoc secondary analysis. Crit Care. Published 29 December 2025. doi:10.
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