Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial
Authors' conclusion
In critically ill patients with severe AKI, initiation of CRRT, as compared to IHD, was associated with a significant reduction in the composite outcome of death or RRT dependence at 90-days.
Study context
- Population
- Critically ill patients with severe acute kidney injury (AKI) in the STARRT-AKI trial
- Participants
- 1,590 vs 606
- Comparison
- Initial continuous renal replacement therapy (CRRT) vs intermittent hemodialysis (IHD)
- CRRTn = 1,590
- IHDn = 606reference
- Primary endpoint
- Composite of:
- Death
- RRT dependence
- Follow-up
- 90 days after randomization
Methodological detailspropensity score, inverse probability of treatment with overlap-weighting
- Propensity score
- Inverse probability of treatment with overlap-weighting
Primary result
As reported in the abstract
CRRT vs IHDEstimate (95% CI)
CRRT
unadjusted OR 0.90(0.75–1.09)
Overlap-weighted
OR 0.81(0.66–0.99)
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| RRT dependence · 90 days | 0.61 (0.39–0.94) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med. Published 10 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →