Initial renal replacement therapy (RRT) modality associates with 90-day postdischarge RRT dependence in critically ill acute kidney injury (AKI) survivors
Main findingResult — go to the resultWeighted adjusted odds ratio 0.68 95% CI 0.47–0.97Authors' conclusion
Adjusted for potential confounders, the odds of RRT dependence at 90 days postdischarge among survivors of RRT for AKI was 30% lower for those treated first with CRRT vs. IHD, overall and in several sensitivity analyses.
Study context
- Population
- Adult intensive care units (ICU) patients discharged alive after RRT for AKI, US Premier PINC AI Healthcare Database, January 1, 2018 to June 30, 2021
- Participants
- 3,804 patients · 382 hospitals
- Exposure
- Initial continuous renal replacement therapy (CRRT) vs intermittent hemodialysis (IHD)
- CRRTn = 1,064
- IHDn = 2,740reference
- Outcome
- RRT dependence (≥2 RRT treatments in the last 8 days)
- Follow-up
- 90 days postdischarge
Methodological detailsinverse probability treatment weighting, claims-linked hospital discharge database
- Inverse probability treatment weighting
- Claims-linked hospital discharge database
Main finding
As reported in the abstract
Weighted adjusted odds ratio
0.68
95% CI 0.47–0.97
P = 0.03
By group
CRRT vs IHD
weighted aOR 0.68 (95% CI 0.47–0.97); P = 0.03
Observational data: associations, not effects.
Further findings
RRT dependence at hospital discharge
P = 0.04
Sensitivity analyses (including deaths days 1-90, n = 112; excluding IHD-only hospitals, n = 335; excluding modality switchers, n = 451)
- Results persisted
Original publication
Initial renal replacement therapy (RRT) modality associates with 90-day postdischarge RRT dependence in critically ill AKI survivors. J Crit Care. Published 8 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →