Association of vasopressor use during renal replacement therapy and mortality
Authors' conclusion
In summary, vasopressor use during the 3 days post-RRT initiation was independently and incrementally associated with higher in-hospital mortality in patients receiving either CRRT or IHD as the first modality.
Study context
- Population
- Critically ill adults with acute kidney injury (AKI) requiring renal replacement therapy (RRT) in US hospitals, discharged January 1, 2018 to June 30, 2021
- Participants
- 20,882 adults
- Exposure
- CRRT vs IHD
- CRRTn = 7,660
- IHDn = 13,222
- Outcome
- In-hospital mortality
Methodological detailsadministrative database (PINC AI Healthcare Database), risk-adjusted
- Administrative database (PINC AI Healthcare Database)
- Risk-adjusted
Main finding
As reported in the abstract
Risk-adjusted in-hospital mortality, vasopressor exposure post-RRT initiation vs none
Adjusted hazard ratio (95 % CI)
Vasopressors (CRRT) vs No vasopressors (CRRT)
1.69(1.55–1.85)
Vasopressors (IHD) vs No vasopressors (IHD)
1.72(1.61–1.84)
Observational data: associations, not effects.
Further findings
In-hospital mortality by number of vasopressors (CRRT)
| aHR (95 % CI) | ||
|---|---|---|
| 1 vasopressor | 1.50 (1.36–1.65) | |
| 2 vasopressors | 1.94 (1.76–2.14) | |
| 3 vasopressors | 2.06 (1.72–2.46) | |
| 0.512Adjusted hazard ratio (log scale) |
In-hospital mortality by number of vasopressors (IHD)
| aHR (95 % CI) | ||
|---|---|---|
| 1 vasopressor | 1.57 (1.47–1.68) | |
| 2 vasopressors | 2.20 (2.02–2.40) | |
| 3 vasopressors | 2.32 (1.82–2.96) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Association of vasopressor use during renal replacement therapy and mortality. J Crit Care. Published 7 May 2025. doi:10.
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