ICU sedation, delirium & recovery
Impact of acute kidney injury on major adverse cardiovascular events in intensive care survivors
Main finding · MACEResult — go to the resultHazard ratio 1.38 95% CI 1.12–1.70Authors' conclusion
One in 10 ICU survivors experiences a major adverse cardiovascular event after discharge. Acute kidney injury whilst in ICU was associated with an increased risk of major adverse cardiovascular events and specifically myocardial injury.
Study context
- Population
- ICU survivors of an admission to one of two ICUs, July 2015–June 2018
- Participants
- 3,994 ICU survivors
- Exposure
- AKI vs no AKI during ICU stay
- Outcome
- MACE after discharge:
- Myocardial injury
- Coronary artery intervention
- Radiological evidence of stroke
Methodological detailstwo ICUs, routinely collected data
- Two ICUs
- Routinely collected data
Main finding
MACE
Hazard ratio
1.38
95% CI 1.12–1.70
P = 0.003
AKI vs No AKI
HR 1.38 (95% CI 1.12–1.70); P = 0.003
As reported in the abstract
- MACE in all ICU survivors: 385 patients
- 9.6% (95% CI 8.8-10.6%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Biochemical myocardial injury | 1.48 (1.16–1.89) | P = 0.001 | |
| 0.512Hazard ratio (log scale) |
Coronary artery interventions and cerebrovascular events
- No statistically significant association with AKI
Original publication
Impact of acute kidney injury on major adverse cardiovascular events in intensive care survivors. BJA Open. Published 3 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →