Cardiothoracic & vascular anesthesia
Impact of Cardiopulmonary Bypass Duration on the Renal Effects of Amino Acids Infusion in Cardiac Surgery Patients
Authors' conclusion
Cardiac surgery patients with prolonged CPB exposure had a significantly higher incidence of AKI. Notably, the P-CPB group received a greater benefit from AA therapy with an absolute risk and relative risk reduction of both any and severe AKI compared with the B-CPB group.
Study context
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass (CPB)entire PROTECTION trial population
- Participants
- 3,511 adults
- Comparison
- Amino acids (AA) infusion vs placebo by CPB duration
- B-CPBn = 1,716reference
- P-CPBn = 1,723
- Primary endpoint
- AKI incidence
Methodological detailsmulticentre, international, double-blind, placebo-controlled
- Multicentre
- International
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
AKI
Relative risk (95% CI)P value
B-CPB vs P-CPB
0.64(0.57–0.71)
P < 0.001AA vs PlaceboP-CPB subgroup
0.79(0.70–0.90)
P < 0.001- Absolute risk reduction with AA in P-CPB (32% vs 40%)
- 8%
- NNT with AA in P-CPB
- 14
Further findings
| Outcome | AA | Placebo | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| AKI stage 3, AA vs placebo | 2.2% | 5.0% | 0.45 (0.26–0.76) | P < 0.001 | |
| 0.20.5125Relative risk (log scale) |
- Acute kidney injury (AKI) stage 3, AA vs placebo: >95% probability of effect being greater in P-CPB vs B-CPB
Original publication
Impact of Cardiopulmonary Bypass Duration on the Renal Effects of Amino Acids Infusion in Cardiac Surgery Patients. J Cardiothorac Vasc Anesth. Published 2 June 2025. doi:10.
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