Respiratory failure & ventilation
Impact of Early Tracheostomy Versus Late or No Tracheostomy in Nonneurologically Injured Adult Patients: A Systematic Review and Meta-Analysis*
Pooled resultResult — go to the resultRelative risk 0.91 95% CI 0.82–1.01Authors' conclusion
In our systematic review, we observed that early tracheostomy, as compared with late tracheostomy or prolonged intubation, was not associated with a reduction in overall mortality.
Study context
- Population
- Nonneurologically injured mechanically ventilated critically ill adults
- Participants
- 2,457 participants · 9 RCTs
- Comparison
- Early tracheostomy vs late tracheostomy or prolonged intubation
- Outcome
- Overall mortality
Methodological detailstrial sequential analysis, GRADE
- Trial sequential analysis
- GRADE
Pooled result
As reported in the abstract
Relative risk
0.91
95% CI 0.82–1.01
Early tracheostomy vs Late tracheostomy or prolonged intubation
RR 0.91 (95% CI 0.82–1.01)
Further pooled results
Subgroup analyses (subgroup)
- Results consistent in all subgroup analyses
ICU and hospital LOS, duration of mechanical ventilation, VAP
- No differences observed
Safety
Complications
- No differences observed
Original publication
Impact of Early Tracheostomy Versus Late or No Tracheostomy in Nonneurologically Injured Adult Patients: A Systematic Review and Meta-Analysis*. Crit Care Med. Published 7 December 2022. doi:10.
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