Respiratory failure & ventilation
Prolonged Mechanical Ventilation in Critically Ill Patients: Six-Month Mortality, Care Pathways, and Quality of Life
Authors' conclusion
Our results show that three-quarters of patients receiving PMV who were discharged alive were weaned, but their HrQoL was reduced.
Study context
- Population
- ICU patients receiving invasive prolonged mechanical ventilation (≥ 21 days via endotracheal tube/tracheostomy or ≥ 4 days via tracheostomy)69 discharged alive
- Participants
- 90 patients
- Comparison
- Successfully weaned vs unsuccessfully weaned prolonged mechanical ventilation (PMV) patients
- Successfully weanedn = 52
- Unsuccessfully weanedn = 17reference
Methodological details2 ICU clusters, 6-month follow-up after ICU discharge
- 2 ICU clusters
- 6-month follow-up after ICU discharge
Primary result
As reported in the abstract
Mortality and weaning · 6 months after ICU discharge
Died (21 in the ICU, 20 within 6 months after ICU discharge)
46%
41 of 90 patients
Could not be weaned, of those discharged alive
25%
17 of 69 patients
Successfully weaned within 6 months, of those discharged alive
75%
52 of 69 patients
Further findings
Median
| Outcome | Successfully weaned | Unsuccessfully weaned | P value |
|---|---|---|---|
| Care place transitions · 6 months | 4 (IQR 2–5) | 2 (IQR 1–3) | P = 0.004 |
| Quality-adjusted life days · 6 months | 73.1 (IQR 23.2–135) | 0 (IQR 0–32.6) | P = 0.002 |
- Care place transitions — All patients, median care place transitions (Q1, Q3: 2, 5)
- 3
Readmission rate, all patients · 6 months
- Readmission rate
- 46%
Care pathways
- One-half of successfully weaned transitioned home; unsuccessfully weaned mostly transitioned from weaning centers to nursing homes or died
Original publication
Prolonged Mechanical Ventilation in Critically Ill Patients: Six-Month Mortality, Care Pathways, and Quality of Life. Chest. Published 27 January 2025. doi:10.
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