ICU sedation, delirium & recovery
Health-related quality of life correlates with patient-reported and proxy-reported disability in critical illness survivors: a secondary analysis of the ERIC trial
Authors' conclusion
Our results suggest a high correlation between the patient-reported and proxy-reported WHODAS 2.0 and the EQ-5D-5L, particularly in their corresponding domains.
Study context
- Population
- Critical illness survivors and caregivers at follow-up 6 months after ICU dischargeanalysed
- Participants
- 700 survivors
- Comparison
- EQ-5D-5L vs patient-reported and proxy-reported 12-item WHO Disability Assessment Schedule (WHODAS) 2.0
- Primary endpoint
- Relationship between EQ-5D-5L index value and WHODAS 2.0 sum scores (global and domain-specific)
- Follow-up
- 6 months after ICU discharge
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Correlation of EQ-5D-5L index value with WHODAS 2.0 sum scores
Spearman correlation, EQ-5D-5L index vs patient-reported WHODAS 2.0 sum score (95% CI - 0.86 to - 0.82)
- 0.84
Spearman correlation, EQ-5D-5L index vs proxy-reported WHODAS 2.0 sum score (- 0.76 to - 0.64)
- 0.70
Further findings
Instrument scores
- Median EQ-5D-5L index value [IQR 0.52 to 0.94]
- 0.81
- Median patient-reported WHODAS 2.0 sum score [IQR 3 to 23]
- 11
- Median proxy-reported WHODAS 2.0 sum score [IQR 6 to 28]
- 16
Ceiling and floor effects
- Ceiling and floor effects for both instruments, limiting detection of mild disabilities and high health-related quality of life (HrQoL)
Multivariable linear regression: WHODAS 2.0 as predictor of EQ-5D-5L index value
- Patient-reported and proxy-reported WHODAS 2.0 sum scores, both coefficient (95% CI - 0.02 to - 0.02, p < 0.01)
- WHODAS 2.0 domain scores for mobility, self-care and life activities predicted respective EQ-5D-5L domain scores
Original publication
Health-related quality of life correlates with patient-reported and proxy-reported disability in critical illness survivors: a secondary analysis of the ERIC trial. Crit Care. Published 23 April 2025. doi:10.
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