Respiratory failure & ventilation
Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study
An erratum to this article was published (Ann Intensive Care, 28 Apr 2025 ↗)
Authors' conclusion
Frailty status had a more consistent impact than older age on weaning outcomes.
Study context
- Population
- Patients on invasive mechanical ventilation (MV) enrolled in the WEAN SAFE study
- Participants
- 760 / 360 / 197 / 3,176
- Comparison
- Frail, elderly, and frail and elderly vs not frail or elderly
- Frailn = 760
- Elderlyn = 360
- Frail and elderlyn = 197
- Not frail or elderlyn = 3,176reference
- Primary endpoint
- Delayed weaning and failed weaning from invasive MV
Primary result
As reported in the abstract
Delayed weaning; failed weaning
Delayed weaning; failed weaning Frail 28 and 23% · Elderly 25 and 19% · Frail and elderly 22% and 25% · Not frail or elderly 12% and 13%
Delayed weaning
Failed weaning
- Frail, Elderly, Frail and elderly vs Not frail or elderly: P < 0.01 — significantly higher
Secondary outcomes
ICU and hospital mortality — Frail, Elderly, Frail and elderly vs Not frail or elderly · higher Frail 21 and 33% · Elderly 19 and 31% · Frail and elderly 26 and 46% · Not frail or elderly 12% and 18% · P < 0.001
ICU mortality
Hospital mortality
Original publication
Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study. Ann Intensive Care. Published 20 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →