Respiratory failure & ventilation
Impact of comorbidities on management and outcomes of patients weaning from invasive mechanical ventilation: insights from the WEAN SAFE study
Authors' conclusion
Most patients weaning from invasive ventilation have comorbidities, which are associated with higher weaning failure risk and worse outcomes.
Study context
- Population
- Patients enrolled in the WEAN SAFE study who commenced weaning from invasive mechanical ventilation
- Participants
- 4,523 patients
- Comparison
- Number of comorbidities and specific comorbidity type
- Nonen = 1,562reference
- 1n = 1,614
- 2n = 889
- 3 plusn = 432
- Primary endpoint
- Impact of comorbidities on delayed weaning and failed weaning from invasive MV
Primary result
As reported in the abstract
Delayed and failed weaning from invasive MV
- Proportion with failed weaning increased progressively with increasing comorbidities
- Patients with comorbidities more likely to fail a separation attempt, receive an extubation attempt, and require >1 extubation attempt
- Neuromuscular comorbidities associated with increased weaning duration
- Weaning failure increased with respiratory, hepatic, renal, neuromuscular, and immune dysfunction comorbidities
Secondary outcomes
Hospital mortality
Hospital mortality
- Hospital mortality increased progressively with number of comorbidities
- Each specific comorbidity independently associated with increased hospital mortality
Decisions to limit life-sustaining interventions
- Presence of comorbidities associated with decisions to limit life-sustaining interventions
Original publication
Impact of comorbidities on management and outcomes of patients weaning from invasive mechanical ventilation: insights from the WEAN SAFE study. Crit Care. Published 13 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →