Respiratory failure & ventilation
Management and outcomes in women and men weaning from invasive mechanical ventilation: insights from the WEAN SAFE study
Authors' conclusion
Women weaning from ventilation were shorter and had less severe respiratory failure but received less protective lung ventilation and more frequent ventilatory over-assistance. When adjusted for height and age, female sex was not independently associated with failed weaning from invasive ventilation.
Study context
- Population
- Patients who commenced weaning from invasive mechanical ventilation in the WEAN SAFE cohortentered weaning
- Participants
- 4,523 patients
- Comparison
- Women vs men
- Womenn = 1,754
- Menn = 2,769reference
- Primary endpoint
- Effect of sex on delayed weaning and failed weaning from invasive mechanical ventilation
Primary result
As reported in the abstract
Weaning success
- Univariate: women less likely to successfully wean from invasive ventilation
- Adjusted for height, age, frailty: no independent association between sex and weaning success
Secondary outcomes
Ventilatory management
- Women received higher tidal volumes and lower PEEP than men; higher driving pressures on controlled and higher inspiratory pressures on assisted ventilation
- Female sex and shorter stature independently associated with higher tidal volume ventilation
Ventilatory support, weaning management and outcomes (P/F ratios <200) (subgroup)
- No sex differences
Original publication
Management and outcomes in women and men weaning from invasive mechanical ventilation: insights from the WEAN SAFE study. Ann Intensive Care. Published 20 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →