Respiratory failure & ventilation
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
An erratum to this article was published (Lancet Respir Med, Mar 2023 ↗)
Authors' conclusion
In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days.
Study context
- Population
- Adults (>16 years) in 481 ICUs in 50 countries receiving invasive mechanical ventilation for ≥2 calendar daysenrolled
- Participants
- 5,869 adults
- Outcome
- Proportion of patients successfully weaned (no reintubation or death within 7 days of extubation)
- Follow-up
- 90 days
Methodological detailsinternational, multicentre, Oct 4, 2017, to June 25, 2018; 10 232 screened
- International
- Multicentre
- Oct 4, 2017, to June 25, 2018; 10 232 screened
Main finding
As reported in the abstract
Successfully weaned from ventilation at day 90
3817
65.0%
Observational data: associations, not effects.
Secondary outcomes
At least one separation attempt
- Underwent at least one separation attempt
- 4523 (77.1%)
Transfer and death before successful weaning
- Transferred before any separation attempt
- 237 (4.0%)
- Transferred after ≥1 separation attempt, not successfully weaned
- 153 (2.6%)
- Died while invasively ventilated
- 1662 (28.3%)
Time from fulfilling weaning eligibility criteria to first separation attempt
- Median time, days (IQR 0-4)
- 1
- Delay in initiating first separation of ≥5 days
- 1013 (22.4%)
Weaning category among patients with separation attempts (n = 4523)
- Short wean (≤1 day)
- 2927 (64.7%)
- Intermediate weaning (2-6 days)
- 457 (10.1%)
- Prolonged weaning (≥7 days)
- 433 (9.6%)
- Weaning failure
- 706 (15.6%)
Factors associated with delayed weaning initiation and weaning failure
- Higher sedation scores independently associated with delayed initiation of weaning
- Delayed initiation of weaning and higher sedation scores independently associated with weaning failure
ICU and hospital mortality
- Died in ICU (of 5479)
- 1742 (31.8%)
- Died in hospital (of 5465)
- 2095 (38.3%)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →