Neuroanesthesia & neurocritical care
Impact of hyperoxia and phenylephrine on cerebral oxygenation: An experimental clinical study
Authors' conclusion
In patients undergoing craniotomy under general anaesthesia, brain tissue oxygen tension increased with a high inspiratory oxygen fraction but remained unchanged after a bolus dose of phenylephrine.
Study context
- Population
- Adults scheduled for elective craniotomy under GAcomplete data in 11 + six
- Participants
- 17 adults
- Comparison
- PbtO2 before vs after FiO2 increase from 0.30 to 0.80, and before vs after a phenylephrine bolus
- 30% oxygenn = 11reference
- 80% oxygenn = 11
- Before phenylephrinen = 6reference
- After phenylephrinen = 6
- Outcome
- Brain tissue oxygen tension (PbtO2) in white matter peripherally in the surgical field
Methodological detailsbefore-after comparison
- Before-after comparison
Main finding
As reported in the abstract
PbtO2
80% oxygen vs 30% oxygen: P = 0.004 · After phenylephrine vs Before phenylephrine: P = 0.56
Original publication
Impact of hyperoxia and phenylephrine on cerebral oxygenation: An experimental clinical study. Acta Anaesthesiol Scand. Published 4 October 2022. doi:10.
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