Cardiac arrest & resuscitation
Impact of inhaled sedation on delirium incidence and neurological outcome after cardiac arrest – A propensity-matched control study (Isocare)
Authors' conclusion
In this propensity-matched control study, isoflurane sedation during the post-resuscitation care of ICU patients was associated with a lower incidence of delirium, a shorter duration of mechanical ventilation and a reduced ICU length of stay.
Study context
- Population
- Patients admitted to a medical ICU after cardiac arrest
- Participants
- 510 patients
- Exposure
- Isoflurane vs Intravenous sedation
- Isofluranen = 109
- Intravenous sedationn = 401reference
- Outcome
- Delirium incidence
Methodological detailssingle-centre, historical control
- Single-centre
- Historical control
Main finding
As reported in the abstract
p 0.03
Observational data: associations, not effects.
Further findings
Good neurologic outcome at ICU discharge (CPC ≤ 2) · matched-pair analysis
p 0.47
Ventilation duration
p 0.01
ICU LOS
p 0.01
Mortality
- Isoflurane had no impact on mortality
Original publication
Impact of inhaled sedation on delirium incidence and neurological outcome after cardiac arrest – A propensity-matched control study (Isocare). Resuscitation. Published 13 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →